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Why would a nurse administer a large dose of a drug first followed by a lower dose?

  1. Achieve a therapeutic dose more quickly

  2. Decrease the absorption rate of this drug

  3. Increase the absorption rate of this drug

  4. Prevent a toxic concentration of the drug

The correct answer is: Achieve a therapeutic dose more quickly

Administering a large dose of a drug first followed by a lower dose is done to achieve a therapeutic dose more quickly. This dosing strategy is known as a loading dose, and it is useful in situations where the goal is to rapidly bring the drug concentration in the body to the desired therapeutic level. This approach is commonly used with certain medications to help patients experience the benefits of the drug sooner. Options B, C, and D are incorrect: - Option B, decreasing the absorption rate of the drug, would not be a reason to administer a large dose followed by a lower dose. - Option C, increasing the absorption rate of the drug, is also not a goal of administering a loading dose followed by a lower dose. - Option D, preventing a toxic concentration of the drug, would typically involve careful monitoring of drug levels and adjusting the dosing regimen accordingly, rather than administering a large dose followed by a lower dose.