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Which statement reflects an understanding of phase 2 of the graded dose-response?

  1. Very few target cells have been affected by the drug

  2. This is the measure of the safety margin of the drug

  3. Increasing the drug dose will produce no additional therapeutic response

  4. The client's response is based on the amount of drug given

The correct answer is: The client's response is based on the amount of drug given

Phase 2 of the graded dose-response relationship is the phase where increasing the drug dose does not produce any additional therapeutic response because most target cells have already been affected by the drug. Therefore, the correct answer is D. Option A is not correct because in phase 2, a significant portion of target cells have been affected by the drug. Option B is not correct because the safety margin of the drug is not specifically addressed in phase 2 of the graded dose-response. Option C is not correct because in phase 2, further increasing the drug dose does not lead to any additional therapeutic response.