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What is one reason a newer antihypertensive drug works more effectively than an older drug?

  1. It affects cells' receptors in a different way

  2. Receptors tend to 'burn out', so newer drugs are required

  3. It is a trial and error process until the drug is effective

  4. Newer drugs affect protein receptor-complexes differently

The correct answer is: It affects cells' receptors in a different way

Newer antihypertensive drugs may work more effectively than older drugs because they affect cells' receptors in a different way. This difference in mechanism of action can lead to increased effectiveness in controlling blood pressure. While the other options provide some insights into drug development and efficacy, the key reason for the effectiveness of newer antihypertensive drugs lies in how they interact with the receptors in the body.