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What happens to the absorption of aspirin in the small intestine when it is ionized?

  1. Absorption is decreased

  2. Absorption is increased

  3. Aspirin must travel past the small intestine for absorption to occur

  4. Ionization has nothing to do with absorption rate

The correct answer is: Absorption is decreased

When aspirin is in its ionized form, it is less readily absorbed in the small intestine. This is because ionized substances have a harder time crossing cell membranes due to their charge. Therefore, the absorption of aspirin is decreased when it is in its ionized form. Option B is incorrect because absorption is actually decreased, not increased, when aspirin is ionized. Option C is also incorrect as aspirin can still be absorbed in the small intestine, but its rate of absorption is affected by its ionization state. Lastly, option D is incorrect as ionization indeed plays a role in the absorption rate of aspirin in the small intestine.